Need/Opportunity

Breast Cancer is a global problem. In the U.S. nearly one in eight women will develop Breast Cancer in their lifetime. This translates to > 200,000 new cases of Breast Cancer and, despite existing therapies, > 40,000 deaths per year in U.S. Importantly, there is also an unmet need for targeted therapy for highly aggressive triple negative Breast Cancer. JAA-F11 can meet these needs targeting 80% of all Breast Cancer (competitor Herceptin targets only 25% with Her-2).

Our technology will treat primary and metastatic cancer. Given that cancer deaths are mostly due to metastasis and TF-Ag plays a critical role in the metastasis process, JAA-F11 has long term potential to block metastasis extending patient survival. JAA-F11 is expected to be safe as humans have small amounts of naturally occurring antibody to the TF-Ag. Recent in vivo efficacy studies show potential for lung cancer as well.

Our main competitor Herceptin immunotherapy (targeting 25% of BrCa), generated >$6 billion in revenue in 2014 with ~7% growth in market per year. The market for hJAA-F11 targeting 80% of all Breast Cancer may potentially generate up to $19.2 billion/year.